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Corticobasal degeneration (CBD) is a rare condition that can cause gradually worsening problems with movement, speech, memory and swallowing. It's often also called corticobasal syndrome (CBS). CBD is caused by increasing numbers of brain cells becoming damaged or dying over time. The symptoms of CBD get gradually worse over time. They are very variable and many people only have a few of them. One limb is usually affected at first, before spreading to the rest of the body. The rate at which the symptoms progress varies widely from person to person. Read more about the symptoms of CBD. CBD occurs when brain cells in certain parts of the brain are damaged as a result of a build-up of a protein called tau. The surface of the brain (cortex) is affected, as well as a deep part of the brain called the basal ganglia. Tau occurs naturally in the brain and is usually broken down before it reaches high levels. In people with CBD, it isn't broken down properly and forms harmful clumps in brain cells.
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